Corpse Killer is a game released for the Sega CD, Sega CD 32X, 3DO, Sega Saturn, Windows 95 and Macintosh computers that features live action full motion video in a format similar to other games developed by Digital Pictures. The quality of the full motion video on the Sega CD version is less than that of the others. Also, after the release of the Sega CD version, Digital Pictures created an option to have English subtitles during the full motion video as critics had complained that it was difficult to understand what the driver was saying in the Sega CD and Sega 32X versions. Corpse Killer was the first CD game released for the Sega 32X.
Footage from the game was later recycled for the 2003 film Game Over.
An unnamed United States Marine is airdropped onto a tropical island on a top secret mission to stop the evil Dr. Hellman, who plans to release his army of zombies on the world. He is bitten by a zombie and also meets an attractive female reporter and a Rastafarian male driver. Four of the marine lieutenant's comrades are captured by Hellman and turned into zombies. To rescue them, the lieutenant infiltrates Hellman's compound and shoots each of them with bullets coated with extract from Datura plants, which can turn freshly created zombies back into humans.
Most of the gameplay is similar to other shooting full motion video games such as Lethal Enforcers. The player moves through the jungle shooting various zombies, collecting better ammunition (to prepare for a raid on Hellman's compound) and medicine to recover health.
The Sega Saturn version of the title was released with the subtitle of "Graveyard Edition". This version features a few exclusives such as full-screen video (other versions have the FMV boxed in), improved video quality, a difficulty select (ranging from normal to bloodthirsty to cannibal), items and power-ups that drop down from the top of the screen and can be shot and collected, and "in your face" zombie attacks. These attacks involve a zombie that pops up immediately in front of the "camera" and attacks the player. They can only be killed with armor-piercing rounds or Datura rounds. The Saturn version is also the only version of the game to lack light gun support (though there is no mention of light guns in the manual or packaging for the 3DO version, it does in fact include light gun support).